A Calcium Alginate Hydrogel Microsphere‐Based Transcatheter Arterial Viroembolization Strategy for Hepatocellular Carcinoma

Abstract Oncolytic adenoviruses (OAs)‐based virotherapy can regulate the tumor microenvironment, providing a rational strategy for combination treatment with other therapy techniques, such as transcatheter arterial embolization (TAE). Here, novel, validated viroembolization (TAVE) strategy—a calcium alginate hydrogel microsphere OA encapsulated (OA@Alg beads) to achieve of TAE oncolytic enhance and prolong antitumor efficacy in hepatocellular carcinoma treatment—is described. The OA@Alg beads show excellent vascular rabbit hepatic VX2 model, resulting successful occlusion arteries. Importantly, enable sustained release maintain their bioactivity extended periods while preventing shedding from site healthy tissues. Moreover, system preserves OA's ability induce an immune response, higher intratumoral infiltration by CD4 + /CD8 T cells. have potential effective embolic TAVE clinical carcinoma.